I've been drilling rims for about 8 years now after thinking one day " well its full of holes already , some more couldn't hurt " . Never had a problem with 2 extra 10mm holes between the spoke holes in a 36 hole rim . Seems to save between 5 and 10 grams a rim on average so not a great saving but if you have a drill and a few bits already it's only costing you time . I haven't done it for a while now as I can't be bothered , it can take a while popping that many holes into 2 rims going from a 2mm bit to a 10mm one .
Modern trials rims are like that so more material can be put into the parts of a rim that need the extra thickness but still keeping the rim in a reasonable weight . So more of an offset than a saving .