Maybe not on the pennine way! Is a bit lumpy/rocky/muddy.
Tho, given ideal conditions, no mechanicals or mishaps, you could possibly do it in 24 hours.
Mate of mine did the 7 day Off Road Tour of the Peaks in one hit, took him 18 odd hours, door to door, that's the thick end of 200 miles. Think he was on a Klein Attitude.