We live in an age where even us mere mortals can build agile robots and combined with artificial intelligence we could fire a bunch of them off into space on a really long mission. Going out into space is about collecting information and studying things and we don't need humans for that.
We could send robots and not worry about feeding them, or any mental and physical health problems and robots don't need the toilet, or menstrate, which means the vehicle can be lighter through not having food stores, toilet systems, gym equipment, etc
We don't though, for things like ISS and new moon landings, because human endeavour and heroism sells and keeps the people interested and space programs get to exist if the people support them. It is they who pay the bills and have kids who might dream of being astronaughts without queationing the costs, too much, until something goes wrong again!
We can't send people out into space, on a trip that may never end ,because, even if those people agree to do so, it will never be acceptable for them to have complicated medical probelms, with zero help, then die and to just keep on floating along without funerals and burials. It will never pass the ethical and religious test and you only have to look at the assisted dying debate to see how far the idea of sending humans out to die in space would get.
An alien species may have a completely different take on things and they will send robots, like the things Boston Dynamics make, on missions and they will spend a very long time on charge, between maintenance tasks, waiting to land somewhere to do science stuff, or maybe meet another species and say hello.
The problem i could see, that could prevent travel over hundreds/thousands of years , is batteries degrading unless they have that nailed. With our current tech even if you took a truck load of boxes of batteries, to use over the years, they will be useless once you get around to using them because they have gradually been dying in storage. They aren't light either!
Assuming aliens would send flesh and blood is a very Hollywood way of looking at the possibility of aliens doing space stuff.