Radial lacing has always been an appearance issue, as it truly does build a weaker wheel (professionally built or not).
While it does save weight, you would still be better off pushing away from the table a bit early than to sacrifice the longevity of your wheel to save a few grams.
As for the torsional forces and stress transferred to the hub flange, you should be fine building radially on a forged hub shell but stay away from any radial lacing on any
Bottom line I guess...if you plan on riding the bike as it was intended, do yourself right and lace up a bomber wheelset. If it is going to be a garage queen, anything goes